InterPAD - DETAILS

SODIUM SELENITE, Disodium selenite, 10102-18-8, Natriumselenit, Selenious acid, disodium salt, Selenious Acid Disodium Salt, disodium;selenite, Selenite sodium, Pleo selene, Sodium selenite anhydrous, Disodium selenium trioxide, CCRIS 1260, HSDB 768, UNII-HIW548RQ3W, EINECS 233-267-9, HIW548RQ3W, Selenious acid, sodium salt (1:2), MFCD00003489, DTXSID0032077, CHEBI:48843, NSC-347466, DTXCID8012077, EC 233-267-9, NSC 347466, 10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt), Sodium selenite (JAN), SODIUM SELENITE [JAN], dinatriumselenit, Natriumselenit [German], SODIUM SELENITE (EP MONOGRAPH), SODIUM SELENITE [EP MONOGRAPH], Selenite, Sodium, Selenite, Disodium, NA2630, Sodium selenite, anhydrous, Aselend, H2-O3-Se.1/2Na, Aselend (TN), Sodium Selenite,(S), 44-46% pound notanhydrous, SODIUM SELENITE [MI], SODIUM SELENITE [HSDB], CHEMBL112302, SODIUM SELENITE [VANDF], SODIUM SELENITE [WHO-DD], SODIUM SELENATE (NA2SEO3), Tox21_202977, SODIUM SELENITE [GREEN BOOK], AKOS015912461, Sodium selenite [NA2630] [Poison], NCGC00260523-01, CAS-10102-18-8, NS00082555, D10530, Q414626, 10102-18-8(disodiumsalt); 7782-82-3(monosodiumsalt, 10102-18-8(disodiumsalt); 7782-82-3(monosodiumsalt)

No.	Title	Href
1	The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines. Afr Health Sci. 2022 Jun;22(2):334-342. doi: 10.4314/ahs.v22i2.37.	`Click`
2	Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. Arch Iran Med. 2016 Jan;19(1):23-9.	`Click`

No.

Title

Href

The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines. Afr Health Sci. 2022 Jun;22(2):334-342. doi: 10.4314/ahs.v22i2.37.

Click

Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. Arch Iran Med. 2016 Jan;19(1):23-9.

Click

Name	Sodium selenite
PubChem CID	24934
Molecular Weight	172.95g/mol
Synonyms	SODIUM SELENITE, Disodium selenite, 10102-18-8, Natriumselenit, Selenious acid, disodium salt, Selenious Acid Disodium Salt, disodium;selenite, Selenite sodium, Pleo selene, Sodium selenite anhydrous, Disodium selenium trioxide, CCRIS 1260, HSDB 768, UNII-HIW548RQ3W, EINECS 233-267-9, HIW548RQ3W, Selenious acid, sodium salt (1:2), MFCD00003489, DTXSID0032077, CHEBI:48843, NSC-347466, DTXCID8012077, EC 233-267-9, NSC 347466, 10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt), Sodium selenite (JAN), SODIUM SELENITE [JAN], dinatriumselenit, Natriumselenit [German], SODIUM SELENITE (EP MONOGRAPH), SODIUM SELENITE [EP MONOGRAPH], Selenite, Sodium, Selenite, Disodium, NA2630, Sodium selenite, anhydrous, Aselend, H2-O3-Se.1/2Na, Aselend (TN), Sodium Selenite,(S), 44-46% pound notanhydrous, SODIUM SELENITE [MI], SODIUM SELENITE [HSDB], CHEMBL112302, SODIUM SELENITE [VANDF], SODIUM SELENITE [WHO-DD], SODIUM SELENATE (NA2SEO3), Tox21_202977, SODIUM SELENITE [GREEN BOOK], AKOS015912461, Sodium selenite [NA2630] [Poison], NCGC00260523-01, CAS-10102-18-8, NS00082555, D10530, Q414626, 10102-18-8(disodiumsalt); 7782-82-3(monosodiumsalt, 10102-18-8(disodiumsalt); 7782-82-3(monosodiumsalt)
Drug Type	Small molecule
Formula	Na₂SeO₃
SMILES	[O-][Se](=O)[O-].[Na+].[Na+]
InChI	1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
InChIKey	BVTBRVFYZUCAKH-UHFFFAOYSA-L
CAS Number	10102-18-8
ChEMBL ID	CHEMBL112302
ChEBI ID	CHEBI:48843
KEGG ID	D10530
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Juglone, Sodium selenite
Partner Name	Juglone
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	ITGB3	hsa3690
	Up-regulation	Expression	ITGB3	hsa3690
In Vitro Model	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
In Vitro Model	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0186
Result	The juglone-NaSe has the potential to be a promising agent especially to inhibit invasion and metastasis in pancreatic cancer treatment. However, more in depth studies are needed to more clearly demonstrate the effects of juglone-selenium.

Pair Name	Ginsenoside Rh2, Sodium selenite
Partner Name	Ginsenoside Rh2
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G1/S phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	Sodium selenite and G-Rh2 combination have a synergistic effect on cell growth inhibition (57%) compared with sodium selenite (25%) and G-Rh2 alone (28%) after 24 hours of treatment